Magnetic Coupling in the Disks around Young Gas Giant Planets

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The boundary relationship of the Concert Schist and the Oonah Quartzite and Slate correlate at Dundas

The boundary between the metasedimentary Concert Schist (Precambrian) and the adjacent correlate of the relatively unmetamorphosed Oonah Quartzite and Slate (also Precambrian) at the western edge of the Concert Schist near its type section on Concert Creek near Dundas, Tasmania, is regarded as marking a sharp transition in degree of deformation and metamorphism. Three cleavages, mineral segregation and quartz recrystallisation were found in the Concert Schist whereas two cleavages and only minor mineral segregation and quartz recrystallisation were found in the Oonah Formation correlate. Quartz optic axes fabrics obtained from psammites in the Concert Schist and Oonah Quartzite and Slate correlate are similar and show relatively weak preferred orientation. These fabrics and fabrics recorded earlier demonstrate that Precambrian strata in Tasmania which are classed as metamorphosed cannot in all cases be distinguished from those that are classed as relatively unmetamorphosed on the basis of quartz optic axes fabrics present in psammites

Study protocol: DEcisions in health Care to Introduce or Diffuse innovations using Evidence (DECIDE)

BACKGROUND: A range of evidence informs healthcare decision-making, from formal research findings to 'soft intelligence' or local data, as well as practical experience or tacit knowledge. However, cultural and organisational factors often prevent the translation of such evidence into practice. Using a multi-level framework, this project will analyse how interactions between the evidence available and processes at the micro (individual/group) and meso (organisational/system) levels influence decisions to introduce or diffuse innovations in acute and primary care within the National Health Service in the UK. METHODS/DESIGN: This study will use a mixed methods design, combining qualitative and quantitative methods, and involves four interdependent work streams: (1) rapid evidence synthesis of relevant literature with stakeholder feedback; (2) in-depth case studies of 'real-world' decision-making in acute and primary care; (3) a national survey and discrete choice experiment; and (4) development of guidance for decision-makers and evaluators to support the use of evidence in decision-making. DISCUSSION: This study will enhance the understanding of decision-makers' use of diverse forms of evidence. The findings will provide insights into how and why some evidence does inform decisions to introduce healthcare innovations, and why barriers persist in other cases. It will also quantify decision-makers' preferences, including the 'tipping point' of evidence needed to shift stakeholders' views. Practical guidance will be shared with healthcare decision-makers and evaluators on uses of evidence to enable the introduction and diffusion of innovation

Gitksan medicinal plants-cultural choice and efficacy

BACKGROUND: The use of plants for healing by any cultural group is integrally related to local concepts of the nature of disease, the nature of plants, and the world view of the culture. The physical and chemical properties of the plants themselves also bear on their selection by people for medicines, as does the array of plants available for people to choose from. I examine use of medicinal plants from a "biobehavioral" perspective to illuminate cultural selection of plants used for medicine by the Gitksan of northwestern British Columbia, Canada. METHODS: Consultant consensus, "intercultural consensus", independent use of the same plants by other cultural groups, and phytochemistry and bioassay results from the literature, were employed in analysis of probable empirical efficacy of plant uses. RESULTS: 70% of 37 Gitksan medicinal plants were used similarly by other cultures where direct diffusion is not known to have occurred; eleven plants, including the eight most frequently mentioned medicinal plants, also show active phytochemicals or bioassays indicating probable physiologically based therapeutic effects. CONCLUSION: Analysis of intercultural consensus revealed that the majority of cultures in the British Columbia region within the plant ranges use the same plants, or closely related species, in similar ways. The rigor of this analysis is effected by the lack of consistent data on all taxa of interest for all cultures within the region

The role of organizational and professional cultures in medication safety: a scoping review of the literature

Purpose: This scoping review explores what is known about the role of organizational and professional cultures in medication safety. The aim is to increase our understanding of ‘cultures’ within medication safety and provide an evidence base to shape governance arrangements. / Data sources: Databases searched are ASSIA, CINAHL, EMBASE, HMIC, IPA, MEDLINE, PsycINFO and SCOPUS. / Study selection: Inclusion criteria were original research and grey literature articles written in English and reporting the role of culture in medication safety on either organizational or professional levels, with a focus on nursing, medical and pharmacy professions. Articles were excluded if they did not conceptualize what was meant by ‘culture’ or its impact was not discussed. / Data extraction: Data were extracted for the following characteristics: author(s), title, location, methods, medication safety focus, professional group and role of culture in medication safety. / Results of data synthesis: A total of 1272 citations were reviewed, of which, 42 full-text articles were included in the synthesis. Four key themes were identified which influenced medication safety: professional identity, fear of litigation and punishment, hierarchy and pressure to conform to established culture. At times, the term ‘culture’ was used in a non-specific and arbitrary way, for example, as a metaphor for improving medication safety, but with little focus on what this meant in practice. / Conclusions: Organizational and professional cultures influence aspects of medication safety. Understanding the role these cultures play can help shape both local governance arrangements and the development of interventions which take into account the impact of these aspects of culture

Gas and Dust Dynamics in Starlight-heated Protoplanetary Disks

Theoretical models of the ionization state in protoplanetary disks suggest the existence of large areas with low ionization and weak coupling between the gas and magnetic fields. In this regime hydrodynamical instabilities may become important. In this work we investigate the gas and dust structure and dynamics for a typical T Tauri system under the influence of the vertical shear instability (VSI). We use global 3D radiation hydrodynamics simulations covering all $360^\circ$ of azimuth with embedded particles of 0.1 and 1mm size, evolved for 400 orbits. Stellar irradiation heating is included with opacities for 0.1- to 10-$\mu$m-sized dust. Saturated VSI turbulence produces a stress-to-pressure ratio of $\alpha \simeq 10^{-4}$. The value of $\alpha$ is lowest within 30~au of the star, where thermal relaxation is slower relative to the orbital period and approaches the rate below which VSI is cut off. The rise in $\alpha$ from 20 to 30~au causes a dip in the surface density near 35~au, leading to Rossby wave instability and the generation of a stationary, long-lived vortex spanning about 4~au in radius and 40~au in azimuth. Our results confirm previous findings that mm size grains are strongly vertically mixed by the VSI. The scale height aspect ratio for 1mm grains is determined to be 0.037, much higher than the value $H/r=0.007$ obtained from millimeter-wave observations of the HL~Tau system. The measured aspect ratio is better fit by non-ideal MHD models. In our VSI turbulence model, the mm grains drift radially inwards and many are trapped and concentrated inside the vortex. The turbulence induces a velocity dispersion of $\sim 12$~m/s for the mm grains, indicating that grain-grain collisions could lead to fragmentation.Comment: ApJ accepte

Absolute Quantification of Uric Acid in Human Urine Using Surface Enhanced Raman Scattering with the Standard Addition Method.

High levels of uric acid in urine and serum can be indicative of hypertension and the pregnancy related condition, preeclampsia. We have developed a simple, cost-effective, portable surface enhanced Raman scattering (SERS) approach for the routine analysis of uric acid at clinically relevant levels in urine patient samples. This approach, combined with the standard addition method (SAM), allows for the absolute quantification of uric acid directly in a complex matrix such as that from human urine. Results are highly comparable and in very good agreement with HPLC results, with an average <9% difference in predictions between the two analytical approaches across all samples analyzed, with SERS demonstrating a 60-fold reduction in acquisition time compared with HPLC. For the first time, clinical prepreeclampsia patient samples have been used for quantitative uric acid detection using a simple, rapid colloidal SERS approach without the need for complex data analysis

Current practice in the diagnosis and management of sarcopenia and frailty – results from a UK-wide survey

Objectives: Despite a rising clinical and research profile, there is limited information about how frailty and sarcopenia are diagnosed and managed in clinical practice. Our objective was to build a picture of current practice by conducting a survey of UK healthcare professionals. Methods: We surveyed healthcare professionals in NHS organisations, using a series of four questionnaires. These focussed on the diagnosis and management of sarcopenia, and the diagnosis and management of frailty in acute medical units, community settings and surgical units. Results: Response rates ranged from 49/177 (28%) organisations for the sarcopenia questionnaire to 104/177 (59%) for the surgical unit questionnaire. Less than half of responding organisations identified sarcopenia; few made the diagnosis using a recognised algorithm or offered resistance training. The commonest tools used to identify frailty were the Rockwood Clinical Frailty Scale or presence of a frailty syndrome. Comprehensive Geriatric Assessment was offered by the majority of organisations, but this included exercise therapy in less than half of cases, and medication review in only one-third to two-thirds of cases. Conclusions: Opportunities exist to improve consistency of diagnosis and delivery of evidence-based interventions for both sarcopenia and frailty

Global Hydromagnetic Simulations of Protoplanetary Disks with Stellar Irradiation and Simplified Thermochemistry

Outflows driven by large-scale magnetic fields likely play an important role in the evolution and dispersal of protoplanetary disks, and in setting the conditions for planet formation. We extend our 2-D axisymmetric non-ideal MHD model of these outflows by incorporating radiative transfer and simplified thermochemistry, with the twin aims of exploring how heating influences wind launching, and illustrating how such models can be tested through observations of diagnostic spectral lines. Our model disks launch magnetocentrifugal outflows primarily through magnetic tension forces, so the mass-loss rate increases only moderately when thermochemical effects are switched on. For typical field strengths, thermochemical and irradiation heating are more important than magnetic dissipation. We furthermore find that the entrained vertical magnetic flux diffuses out of the disk on secular timescales as a result of non-ideal MHD. Through post-processing line radiative transfer, we demonstrate that spectral line intensities and moment-1 maps of atomic oxygen, the HCN molecule, and other species show potentially observable differences between a model with a magnetically driven outflow and one with a weaker, photoevaporative outflow. In particular, the line shapes and velocity asymmetries in the moment-1 maps could enable the identification of outflows emanating from the disk surface.Comment: 35 pages, 20 figures, accepted for publication in Ap

Optimisation-based Framework for Resin Selection Strategies in Biopharmaceutical Purification Process Development

This work addresses rapid resin selection for integrated chromatographic separations when conducted as part of a high-throughput screening (HTS) exercise during the early stages of purification process development. An optimisation-based decision support framework is proposed to process the data generated from microscale experiments in order to identify the best resins to maximise key performance metrics for a biopharmaceutical manufacturing process, such as yield and purity. A multiobjective mixed integer nonlinear programming (MINLP) model is developed and solved using the ε-constraint method. Dinkelbach's algorithm is used to solve the resulting mixed integer linear fractional programming (MILFP) model. The proposed framework is successfully applied to an industrial case study of a process to purify recombinant Fc Fusion protein from low molecular weight and high molecular weight product related impurities, involving two chromatographic steps with 8 and 3 candidate resins for each step, respectively. The computational results show the advantage of the proposed framework in terms of computational efficiency and flexibility. This article is protected by copyright. All rights reserved